Author

T. Fedorenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Millman· 4 shared R. Sorek· 4 shared A. Leavitt· 3 shared A. Stokar-Avihail· 3 shared G. Amitai· 3 shared S. Melamed· 3 shared N. Tal· 2 shared A. Bernheim· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

A. Millman

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4 papers

Recent·Most cited

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex

B. Duncan-Lowey, N. Tal, A. G. Johnson, S. Rawson, M. L. Mayer, S. Doron, A. Millman, S. Melamed, T. Fedorenko, A. Kacen, G. Amitai, R. Sorek, P. J. Kranzusch

The paper determines the cryo-EM structure of the RADAR complex, showing RdrB targets mononucleotides and catalyzes ATP-to-ITP conversion to limit phage replication.

Cell · Mar 1, 2023Peer-reviewedBiochemistry

Discovery of phage determinants that confer sensitivity to bacterial immune systems

A. Stokar-Avihail, T. Fedorenko, J. Garb, A. Leavitt, A. Millman, G. Shulman, N. Wojtania, S. Melamed, G. Amitai, R. Sorek

The paper identifies phage determinants that confer sensitivity to bacterial immune systems by analyzing 192 phage mutants escaping 19 defense systems.

bioRxiv · Aug 27, 2022Microbiology

Antiviral defense via nucleotide depletion in bacteria

N. Tal, A. Millman, A. Stokar-Avihail, T. Fedorenko, A. Leavitt, S. Melamed, E. Yirmiya, C. Abraham, G. Amitai, R. Sorek

This study identifies bacterial proteins that deplete specific deoxynucleotides to inhibit phage replication, mirroring the human SAMHD1 antiviral mechanism.

bioRxiv · Apr 26, 2021 · PreprintMicrobiology

Bacterial retrons function in anti-phage defense

A. Millman, A. Bernheim, A. Stokar-Avihail, T. Fedorenko, M. Voichek, A. Leavitt, R. Sorek

This study identifies retrons as anti-phage defense systems in bacteria, showing they confer phage resistance through a three-component mechanism involving RT, non-coding RNA, and an effector protein.

bioRxiv · Jun 21, 2020Microbiology