Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
T. Wein, A. G. Johnson, A. Millman, K. Lange, E. Yirmiya, R. Hadary, J. Garb, F. Steinruecke, A. B. Hill, P. J. Kranzusch, R. Sorek
This study identifies CARD-like domains in bacterial defense systems that activate gasdermin-mediated cell death against phage infection.
bioRxiv · May 28, 2023 · PreprintMicrobiology
S. P. Antine, A. G. Johnson, S. E. Mooney, A. Leavitt, M. Mayer, E. Yirmiya, G. Amitai, R. Sorek, P. Kranzusch
This study reveals the structural basis of the Gabija anti-phage defense complex and identifies a viral immune evasion mechanism through phage-encoded Gad1.
bioRxiv · May 1, 2023Microbiology
A. G. Johnson, M. L. Mayer, S. L. Schaefer, N. K. McNamara-Bordewick, G. Hummer, P. J. Kranzusch
This study determines the structure of a bacterial gasdermin pore and reveals a conserved mechanism of pore assembly and membrane targeting.
bioRxiv · Apr 20, 2023Microbiology
B. Duncan-Lowey, N. Tal, A. G. Johnson, S. Rawson, M. L. Mayer, S. Doron, A. Millman, S. Melamed, T. Fedorenko, A. Kacen, G. Amitai, R. Sorek, P. J. Kranzusch
The paper determines the cryo-EM structure of the RADAR complex, showing RdrB targets mononucleotides and catalyzes ATP-to-ITP conversion to limit phage replication.
Cell · Mar 1, 2023Peer-reviewedBiochemistry
I. N. Boys, A. G. Johnson, M. Quinlan, P. J. Kranzusch, N. C. Elde
The paper identifies poxvirus-encoded proteins that impact inflammasome-mediated defenses through structural homology screens.
bioRxiv · Feb 26, 2023Evolutionary Biology
A. G. Johnson, T. Wein, M. L. Mayer, B. Duncan-Lowey, E. Yirmiya, Y. Oppenheimer-Shaanan, G. Amitai, R. Sorek, P. J. Kranzusch
This study identifies bacterial gasdermin homologs that execute prokaryotic cell death via caspase-like protease activation, revealing an ancient mechanism of regulated cell death shared with animals.
bioRxiv · Jun 7, 2021Microbiology
C. P. Lapointe, R. Grosely, A. G. Johnson, J. Wang, I. S. Fernandez, J. D. Puglisi
This paper investigates how SARS-CoV-2 NSP1 inhibits translation initiation by competing with mRNA for binding to the 40S ribosomal subunit, modulated by eIFs.
bioRxiv · Aug 20, 2020Biophysics
J. Wang, A. G. Johnson, C. P. Lapointe, J. Choi, A. Prabhakar, D.-H. Chen, A. N. Petrov, J. D. Puglisi
The paper investigates how eIF5B facilitates the transition from translation initiation to elongation in yeast using single-molecule fluorescence microscopy.
bioRxiv · Mar 23, 2019Biochemistry
A. G. Johnson, C. P. Lapointe, J. Wang, N. C. Corsepius, J. Choi, G. Fuchs, J. D. Puglisi
This study investigates RACK1's exchange dynamics on and off the ribosome using fluorescent labeling and biochemical analyses, showing its stable binding and limited conformational changes.
bioRxiv · Mar 21, 2019Biochemistry