N. Tal

Diversification of molecular pattern recognition in bacterial NLR-like proteins

The paper shows that KpAvs2 recognizes a different phage protein, Ksap1, during infection compared to heterologous co-expression assays.

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex

The paper determines the cryo-EM structure of the RADAR complex, showing RdrB targets mononucleotides and catalyzes ATP-to-ITP conversion to limit phage replication.

An expanding arsenal of immune systems that protect bacteria from phages

This study identifies 21 new bacterial defense systems against phages through genomic analysis and experiments, revealing novel protein domains and toxin-antitoxin mechanisms involved in anti-phage immunity.

Antiviral defense via nucleotide depletion in bacteria

This study identifies bacterial proteins that deplete specific deoxynucleotides to inhibit phage replication, mirroring the human SAMHD1 antiviral mechanism.

Antiviral activity of bacterial TIR domains via signaling molecules that trigger cell death

This study identifies a bacterial antiviral pathway using TIR domains to produce a signaling molecule that triggers cell death via NAD depletion.

An instructive role for IL7RA in the development of human B-cell precursor leukemia.

This study shows that aberrant IL7RA signaling in human hematopoietic progenitors leads to B-cell differentiation arrest and Ph-like BCP-ALL development in mice.