T. Huby

Obesity-elicited macrophages shape CD9hi progenitor fate to promote adipose tissue fibrosis and dysfunction

This study identifies an interaction between obesity-elicited macrophages and CD9hi progenitors that drives adipose tissue fibrosis and dysfunction in mice and humans.

Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development

The paper shows that loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis by increasing liver cholesterol and reducing cholesterol regulation.

Dietary fibers benefits on glucose homeostasis require type 2 conventional dendritic cells in mice fed a high-fat diet

This study shows that dietary fibers improve glucose tolerance in mice on a high-fat diet by maintaining specific immune cells, and this effect depends on type 2 conventional dendritic cells.

Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism

This study shows that autophagy regulates lipid metabolism in Langerhans cells, preventing their depletion and ferroptosis in the epidermis.

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases

This study shows that tolerogenic dendritic cells promote a gut microbiota that prevents metabolic diseases by enhancing butyrate production and reducing inflammation.

Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytic cells.

This study identifies structural determinants of SR-B1 required for Plasmodium sporozoite entry into hepatocytes using chimeric mouse/human SR-B1 constructs and structure-guided analysis.