SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy
A. M. Horspool, C. Ye, T. Y. Wong, B. P. Russ, K. S. Lee, M. T. Winters, J. R. Bevere, T. Kieffer, I. Martinez, J. Sourimant, A. L. Greninger, R. K. Plemper, J. Denvir, H. A. Cyphert, J. B. Torrelles, , F. H. Damron
This study compares the pathogenicity and immune response of SARS-CoV-2 variants B.1.1.7 and B.1.351 with WA-1 in mice, showing reduced protection from convalescent plasma against the variants.
bioRxiv · May 5, 2021 · PreprintMicrobiology