Author

A. M. Horspool

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. H. Damron· 5 shared J. R. Bevere· 4 shared M. Barbier· 4 shared H. A. Cyphert· 3 shared I. Martinez· 3 shared M. T. Winters· 3 shared T. Y. Wong· 3 shared B. P. Russ· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersImmunology

F. H. Damron

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5 papers

Recent·Most cited

Diet induced obesity and type 2 diabetes drives exacerbated sex-associated disease profiles in K18-hACE2-mice challenged with SARS-CoV-2

K. Lee, B. Russ, T. Wong, A. M. Horspool, M. T. Winters, M. Barbier, J. R. Bevere, I. Martinez, F. H. Damron, H. A. Cyphert

This study shows that diet-induced obesity and type 2 diabetes in female mice worsen SARS-CoV-2 disease outcomes compared to males and normal diet mice.

bioRxiv · Apr 26, 2022 · PreprintImmunology

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

K. S. Lee, T. Y. Wong, B. P. Russ, A. M. Horspool, O. Miller, N. Rader, J. P. Givi, M. T. Winters, Z. Y. Wong, H. A. Cyphert, J. Denvir, P. G. Stoilov, M. Barbier, N. Roan, M. S. Amin, , F. H. Damron

This study compares the pathogenesis of SARS-CoV-2 Delta and Alpha variants in K18-hACE2 mice, finding Delta causes more inflammation, tissue damage, and interferon responses.

bioRxiv · Jan 18, 2022Immunology

Long-term analysis of pertussis vaccine immunity uncovers a memory B cell response to whole cell pertussis immunization that is absent from acellular immunized mice

K. L. Weaver, C. B. Blackwood, A. M. Horspool, G. M. Pyles, E. Sen-Kilic, E. M. Grayson, A. B. Huckaby, W. T. Witt, M. A. DeJong, M. A. Wolf, F. H. Damron, M. Barbier

This study compares long-term immune responses to whole cell and acellular pertussis vaccines in mice, finding unique memory B cell responses in wP-vaccinated mice.

bioRxiv · Oct 1, 2021 · PreprintImmunology

SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy

A. M. Horspool, C. Ye, T. Y. Wong, B. P. Russ, K. S. Lee, M. T. Winters, J. R. Bevere, T. Kieffer, I. Martinez, J. Sourimant, A. L. Greninger, R. K. Plemper, J. Denvir, H. A. Cyphert, J. B. Torrelles, , F. H. Damron

This study compares the pathogenicity and immune response of SARS-CoV-2 variants B.1.1.7 and B.1.351 with WA-1 in mice, showing reduced protection from convalescent plasma against the variants.

bioRxiv · May 5, 2021 · PreprintMicrobiology

Re-investigating the coughing rat model of pertussis to understand Bordetella pertussis pathogenesis

J. Hall, J. Kang, S. M. Kenney, T. Y. Wong, G. J. Bitzer, C. O. Kelly, C. A. Kisamore, D. Boehm, M. A. DeJong, M. A. Wolf, E. Sen-Kilic, A. M. Horspool, J. R. Bevere, M. Barbier, F. H. Damron

This study uses a rat model to compare disease manifestations between two genetically distinct Bordetella pertussis strains, finding that D420 induces more severe coughing and immune responses than Tohama 1.

bioRxiv · Apr 2, 2021Immunology