Author

J. Sourimant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. K. Plemper· 6 shared M. G. Natchus· 4 shared R. Cox· 4 shared A. L. Greninger· 3 shared G. R. Painter· 3 shared L. Martinez-Sobrido· 3 shared C. M. Lieber· 2 shared C. Ye· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersMicrobiology

R. K. Plemper

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6 papers

Recent·Most cited

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

C. M. Lieber, M. Aggarwal, J.-J. Yoon, R. Cox, J. Sourimant, M. Toots, H.-J. Kang, S. K. Johnson, C. A. Jones, Z. M. Sticher, A. Kolykhalov, M. T. Sindaine, S. M. Tompkins, O. Planz, G. R. Painter, , R. K. Plemper

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19

C. M. Lieber, R. Cox, J. Sourimant, J. D. Wolf, K. Juergens, Q. Phung, M. T. Saindane, M. G. Natchus, G. R. Painter, K. Sakamoto, A. L. Greninger, R. K. Plemper

This study evaluates molnupiravir efficacy against SARS-CoV-2 variants in different models, finding VOC-dependent efficacy and sex-based differences in dwarf hamsters.

bioRxiv · Feb 4, 2022 · PreprintMicrobiology

A bifluorescent-based assay for the identification of neutralizing antibodies against SARS-CoV-2 variants of concern in vitro and in vivo

K. Chiem, D. M. Vasquez, J. Silvas, J.-G. Park, M. Piepenbrink, J. Sourimant, M. J. Lin, A. L. Greninger, R. K. Plemper, J. B. Torrelles, M. R. Walter, J. C. de la Torre, J. Kobie, L. Martinez-Sobrido

This paper develops a bifluorescent-based assay to identify neutralizing antibodies against SARS-CoV-2 variants in vitro and in vivo, showing it accurately reflects viral neutralization.

bioRxiv · Jun 28, 2021Microbiology

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

J. Sourimant, C. Lieber, M. Aggarwal, R. Cox, J. Wolf, J.-J. Yoon, M. Toots, C. Ye, Z. Sticher, A. A. Kolykhalov, L. Martinez-Sobrido, G. R. Bluemling, M. G. Natchus, G. R. Painter, R. K. Plemper

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

bioRxiv · May 19, 2021 · PreprintMicrobiology

SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy

A. M. Horspool, C. Ye, T. Y. Wong, B. P. Russ, K. S. Lee, M. T. Winters, J. R. Bevere, T. Kieffer, I. Martinez, J. Sourimant, A. L. Greninger, R. K. Plemper, J. Denvir, H. A. Cyphert, J. B. Torrelles, , F. H. Damron

This study compares the pathogenicity and immune response of SARS-CoV-2 variants B.1.1.7 and B.1.351 with WA-1 in mice, showing reduced protection from convalescent plasma against the variants.

bioRxiv · May 5, 2021 · PreprintMicrobiology

Therapeutic Targeting of Measles Virus Polymerase with ERDRP-0519Suppresses All RNA Synthesis Activity

R. Cox, J. Sourimant, M. Govindarajan, M. G. Natchus, R. K. Plemper

This paper characterizes ERDRP-0519, a small molecule inhibitor of measles virus polymerase, showing it blocks all RNA synthesis activity through a unique mechanism.

bioRxiv · Sep 23, 2020Microbiology