Author

T. Lavstsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

L. Turner· 4 shared I. H. Kana· 2 shared R. W. Jensen· 2 shared T. G. Theander· 2 shared A. B. Ward· 1 shared A. F. Sander· 1 shared A. Murk· 1 shared A. Ongoiba· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

L. Turner

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A system for functional studies of the major virulence factor of malaria parasites

J. Cronshagen, J. Allweier, J. P. Mesen-Ramirez, J. Staecker, A. V. Vaaben, G. Ramon-Zamorano, I. Naranjo, M. Graser, P. Lopez-Barona, S. Ofori, P. W. Jansen, J. Hornebeck, F. Kieferle, A. Murk, E. Martin, , T. Spielmann

The paper develops a system to study PfEMP1, a key malaria parasite virulence factor, by generating parasites expressing a single PfEMP1 variant and enabling genome edits to investigate its function.

bioRxiv · Apr 30, 2024Microbiology

Mosaic and cocktail capsid-virus-like particle vaccines for induction of antibodies against the EPCR-binding CIDRα1 domain of PfEMP1

I. G. Riedmiller, C. Fougeroux, R. W. Jensen, I. H. Kana, A. F. Sander, T. G. Theander, T. Lavstsen, L. Turner

This study tests mosaic cVLP vaccines against PfEMP1 CIDR1 domains in mice, finding comparable antibody responses to single-variant cocktails but no broad cross-reactivity.

bioRxiv · Apr 2, 2024Immunology

Broadly inhibitory antibodies against severe malaria virulence proteins

R. A. Reyes, S. S. R. Raghavan, N. K. Hurlburt, V. Introini, I. H. Kana, R. W. Jensen, E. Martinez-Scholze, M. Gestal-Mato, C. B. Bau, M. L. Fernandez-Quintero, J. R. Loeffler, J. A. Ferguson, W.-H. Lee, G. M. Martin, T. G. Theander, , T. Lavstsen

The paper identifies two human monoclonal antibodies that broadly inhibit PfEMP1's binding to EPCR, a key process in severe malaria pathogenesis.

bioRxiv · Jan 25, 2024Immunology

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection

N. Obeng-Adjei, D. B. Larremore, L. Turner, A. Ongoiba, S. Li, S. Doumbo, T. B. Yazew, K. Kayentao, L. H. Miller, B. Traore, S. K. Pierce, C. O. Buckee, T. Lavstsen, P. D. Crompton, T. M. Tran

The paper analyzes longitudinal antibody responses to PfEMP1 CIDR domain variants and links specific IgG acquisitions to reduced risk of febrile malaria.

bioRxiv · Feb 11, 2020Immunology

Structure-guided design of a synthetic mimic of an EPCR-binding PfEMP1 protein

N. M. Barber, C. Lau, L. Turner, G. Watson, S. Thrane, J. P. A. Lusingu, T. Lavstsen, M. K. Higgins

The paper designs a synthetic PfEMP1 mimic using structural data to elicit antibodies against EPCR-binding PfEMP1, showing nanomolar affinity and cross-reactivity.

bioRxiv · Aug 28, 2019 · PreprintMicrobiology