S. Doumbo

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

Atypical B cells upregulate co-stimulatory molecules during malaria and secrete antibodies with T follicular helper cell support

This study shows that atypical B cells actively respond to acute malaria and have the capacity to produce antibodies with T cell help.

Number and proportion of P. falciparum gametocytes vary from acute infection to chronic parasite carriage despite unaltered sexual commitment rate

The paper compares gametocyte levels and sexual commitment in P. falciparum infections during dry and wet seasons, finding increased mature gametocytes in asymptomatic dry season carriers without changes in sexual commitment.

Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype

This paper shows that repeated Plasmodium falciparum infections reprogram human monocytes to a regulatory phenotype, reducing inflammatory responses during subsequent infections.

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection

The paper analyzes longitudinal antibody responses to PfEMP1 CIDR domain variants and links specific IgG acquisitions to reduced risk of febrile malaria.