Author

T. M. Lima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

R. G. F. Alvim· 4 shared F. F. Marsili· 3 shared J. L. Silva· 3 shared L. R. Castilho· 3 shared A. M. O. Gomes· 2 shared A. M. Vale· 2 shared A. Tanuri· 2 shared C. H. Dumard· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersImmunology

R. G. F. Alvim

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Uncovering the structural flexibility of SARS-CoV-2 glycoprotein spike variants

H. R. S. Arruda, T. M. Lima, R. G. F. Alvim, F. B. A. Victorio, D. P. B. Abreu, F. F. Marsili, K. D. Cruz, P. Sosa-Acosta, M. Quinones-Vega, J. S. Guedes, F. C. S. Nogueira, J. L. Silva, L. R. Castilho, G. A. P. de Oliveira

The paper compares structural flexibility and stability of SARS-CoV-2 spike variants, finding D614G has less hydrophobic surface exposure and trimer persistence, potentially supporting its fitness advantage.

bioRxiv · Apr 20, 2022 · PreprintBiochemistry

Immunogenicity of SARS-CoV-2 trimetric spike protein associated to Poly(I:C) plus Alum

J. d. Santos, L. F. Cruz, A. M. d. Fonseca-Martins, D. O. Maciel, G. G. Perez, V. A. Roncaglia-Pereira, C. H. Dumard, F. H. Guedes da Silva, A. C. V. dos Santos, M. S. Leandro, J. R. M. Ferreira, K. G. Pinto, L. Conde, D. A. S. Rodrigues, M. V. M. Silva, , H. L. de Matos Guedes

This study evaluates a vaccine strategy using Alum and Poly(I:C) adjuvants with SARS-CoV-2 spike protein, showing enhanced antibody and T-cell responses and reduced lung inflammation.

bioRxiv · Oct 5, 2021 · PreprintImmunology

Drug repurposing to face Covid-19: Celastrol, a potential leading drug capable of inhibiting SARS-CoV-2 replication and induced inflammation

C. A. Fuzo, R. B. Martins, T. F. C. Fraga-Silva, M. K. Amstalden, T. Canassa-DeLeo, J. P. Souza, T. M. Lima, L. H. Faccioli, S. C. Franca, V. L. D. Bonato, E. A. Neto, M. Dias-Baruffi

This paper identifies celastrol as a potential drug for treating Covid-19 by inhibiting SARS-CoV-2 replication and reducing IL-6 secretion in infected cells.

bioRxiv · Apr 20, 2021Immunology

Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones.

C. B. Cavazzoni, V. B. Bozza, L. Tostes, B. Maia, L. Mesin, A. Schiepers, J. Ersching, R. L. Neris, J. N. Conde, D. R. Coleho, L. Conde, H. A. Paula-Neto, T. M. Lima, R. G. F. Alvim, L. R. Castilho, , A. M. Vale

The paper investigates the humoral immune response to Zika virus NS1, showing its immunodominance and association with autoreactive and cross-reactive B cell clones.

bioRxiv · Dec 24, 2020Immunology

Potent neutralizing equine antibodies raised against recombinant SARS-CoV-2 spike protein for COVID-19 passive immunization therapy

L. E. R. Cunha, A. A. Stolet, M. A. Strauch, V. A. R. Pereira, C. H. Dumard, A. M. O. Gomes, P. N. C. Souza, J. G. Fonseca, F. E. Pontes, L. G. R. Meirelles, J. W. M. Albuquerque, C. Q. Sacramento, N. Fintelman-Rodrigues, T. M. Lima, R. G. F. Alvim, , J. L. Silva

This study produces potent equine antibodies against SARS-CoV-2 spike protein with high neutralizing titers, supporting a clinical trial for passive immunization therapy.

bioRxiv · Aug 17, 2020 · PreprintImmunology

Infection of human lymphomononuclear cells by SARS-CoV-2

M. C. Pontelli, I. A. Castro, R. B. Martins, F. P. Veras, L. La Serra, D. C. Nascimento, R. S. Cardoso, R. Rosales, T. M. Lima, J. P. Souza, D. B. Caetite, M. H. Lima, J. T. Kawahisa, M. C. Giannini, L. P. Bonjorno, , E. Arruda

This study investigates SARS-CoV-2 infection of human lymphomononuclear cells in vitro and in vivo, finding that monocytes, B cells, and T cells are susceptible to infection and viral replication.

bioRxiv · Jul 28, 2020Microbiology