Author

I. A. Castro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

D. S. Zamboni· 2 shared E. Arruda· 2 shared M. C. Pontelli· 2 shared A. Fabro· 1 shared C. B. Lopez· 1 shared D. B. Caetite· 1 shared D. C. Nascimento· 1 shared D. M. Jorge· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

D. S. Zamboni

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology

I. A. Castro, Y. Yang, V. Gnazzo, D.-H. Kim, S. J. Van Dyken, C. B. Lopez

This study shows that Sendai virus persists in lung innate immune cells, leading to chronic lung disease by upregulating antiviral and inflammatory genes.

bioRxiv · Nov 7, 2023Microbiology

In Vitro Inhibition of SARS-CoV-2 Infection by Bromhexine hydrochloride

R. Martins, I. Ferreira, D. M. Jorge, L. Almeida, J. d. P. Souza, M. C. Pontelli, I. A. Castro, T. Melquiades, R. M. Mendes Viana, D. S. Zamboni, P. Marcato, E. Arruda

This study shows bromhexine hydrochloride inhibits SARS-CoV-2 infection in vitro by targeting TMPRSS2, reducing viral entry and progeny without direct virucidal activity.

bioRxiv · Dec 23, 2022 · PreprintPharmacology & Toxicology

Infection of human lymphomononuclear cells by SARS-CoV-2

M. C. Pontelli, I. A. Castro, R. B. Martins, F. P. Veras, L. La Serra, D. C. Nascimento, R. S. Cardoso, R. Rosales, T. M. Lima, J. P. Souza, D. B. Caetite, M. H. Lima, J. T. Kawahisa, M. C. Giannini, L. P. Bonjorno, , E. Arruda

This study investigates SARS-CoV-2 infection of human lymphomononuclear cells in vitro and in vivo, finding that monocytes, B cells, and T cells are susceptible to infection and viral replication.

bioRxiv · Jul 28, 2020Microbiology