T. Mikawa

Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation

The paper shows that left-right asymmetry in chick embryos begins before the formation of the left-right organizer, detected through biophysical analysis of cellular flows.

Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites

This study uses NMR to show that GRB2's SH3 domains bind PRMs with different affinities and that phosphorylated EGFR binding affects GRB2's structure and domain interactions.

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle

The paper shows centromeres oscillate within clusters near the centrosome and apical-basal axis without crossing between clusters during the cell cycle.

Hyperactivation of L-lactate oxidase by liquid-liquid phase separation

This study shows that L-lactate oxidase forms liquid droplets that enhance enzyme activity by reducing KM and increasing kcat, representing the first report of increased kcat through droplet formation.

Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase

The paper develops an NMR method to determine multi-state structures of proteins and applies it to yeast ubiquitin hydrolase 1, revealing dynamic motions critical for ubiquitin recognition and proteolysis.