T. Moran

N-Acetyl-2-Aminofluorene (AAF): In vivo temporal expression patterns of growth cycle-dependent macromolecular binding constants KD are revealed by primary cultures of premalignant hepatocytes derived from a multi-cyclic hepatocarcinogenic feeding regimen

The paper investigates how macromolecular binding constants of AAF change during hepatocarcinogenesis using primary cultures of premalignant hepatocytes.

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening

The paper develops a TR-FRET assay for SARS-CoV-2 NP detection, enabling high-throughput screening of compounds against SARS-CoV-2 and its variants.

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

This paper develops a high-throughput AlphaLISA assay to detect SARS-CoV-2 nucleocapsid protein, enabling screening of antiviral compounds.

Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2

This paper describes a rapid and reproducible plaque reduction microneutralization assay for identifying neutralizing antibodies and antivirals against SARS-CoV-2, suitable for high-throughput screening.

N-acetyl-2-aminofluorene (AAF) processing in adult rat hepatocytes in primary culture occurs by high-affinity low-velocity and low-affinity high-velocity AAF metabolite-forming systems

This study investigates AAF metabolism in adult rat hepatocytes, identifying two main metabolic systems and their kinetic parameters.

High-affinity low-capacity and low-affinity high-capacity N-acetyl-2-aminofluorene (AAF) macromolecular binding sites are revealed during the growth cycle of adult rat hepatocytes in primary culture

This study identifies two AAF metabolite binding sites in rat hepatocytes during the growth cycle, with different affinities and capacities, and links them to DNA and cytoplasmic proteins.