Author

K. Gorshkov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 5 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Z. Chen· 6 shared W. Zheng· 6 shared C. Klumpp-Thomas· 4 shared M. Pradhan· 4 shared M. Shen· 4 shared M. Xu· 4 shared W. Zhu· 4 shared H. Guo· 3 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersPharmacology & Toxicology

C. Z. Chen

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6 papers

Recent·Most cited

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

M. Xu, M. Pradhan, K. Gorshkov, J. D. Petersen, M. Shen, H. Guo, W. Zhu, C. Klumpp-Thomas, S. Michael, M. Itkin, Z. Itkin, M. R. Straus, J. Zimmerberg, W. Zheng, G. Whittaker, C. Z. Chen

This paper develops a high throughput screening assay using SARS-CoV-2 pseudotyped particles to identify inhibitors of viral entry, finding 7 active compounds effective against both pseudotyped particles and live virus.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening

K. Gorshkov, D. M. Vasquez, K. Chiem, C. Ye, B. Nguyen Tran, J. C. de la Torre, T. Moran, C. Z. Chen, L. Martinez-Sobrido, W. Zheng

The paper develops a TR-FRET assay for SARS-CoV-2 NP detection, enabling high-throughput screening of compounds against SARS-CoV-2 and its variants.

bioRxiv · Jul 3, 2021Pharmacology & Toxicology

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

K. Gorshkov, C. Z. Chen, J. C. de la Torre, L. Z. Martinez-Sobrido, T. Moran, W. Zheng

This paper develops a high-throughput AlphaLISA assay to detect SARS-CoV-2 nucleocapsid protein, enabling screening of antiviral compounds.

bioRxiv · Aug 20, 2020Microbiology

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS- S and MERS-S pseudotyped particles

C. Z. Chen, M. Xu, M. Pradhan, K. Gorshkov, J. Petersen, M. R. Straus, W. Zhu, P. Shinn, H. Guo, M. Shen, C. Klumpp-Thomas, S. G. Michael, J. Zimmerberg, W. Zheng, G. R. Whittaker

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

bioRxiv · Jul 10, 2020Pharmacology & Toxicology

Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research

K. R. Brimacombe, P. C. Scully, T. Zhao, R. T. Eastman, X. Hu, K. Wang, M. Backus, B. Baljinnyam, C. Z. Chen, L. Chen, Y. Cheng, D. P. Davis, K. Duerr, T. Eicher, A. Friedman, , M. D. Hall

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

bioRxiv · Jun 4, 2020 · PreprintBiochemistry

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

K. Gorshkov, C. Z. Chen, R. Bostwick, L. Rasmussen, M. Xu, M. Pradhan, B. N. Tran, W. Zhu, K. Shamim, W. Huang, X. Hu, M. Shen, C. Klumpp-Thomas, Z. Itkin, P. Shinn, , W. Zheng

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

bioRxiv · May 16, 2020Pharmacology & Toxicology