Author

T. N. Seyfried

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

B. Czumbel· 2 shared B. Greenwood· 2 shared C. Chinopoulos· 2 shared D. Bui· 2 shared D. C. Lee· 2 shared G. Pallag· 2 shared M. A. Kiebish· 2 shared N. Karnok· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

B. Czumbel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Viability of HepG2 and MCF-7 Cells is not Correlated with Mitochondrial Bioenergetics

J. Doczi, N. Karnok, D. Bui, V. Azarov, G. Pallag, S. Nazarian, B. Czumbel, T. N. Seyfried, C. Chinopoulos

This study shows that mitochondrial bioenergetics and cell viability are uncorrelated in HepG2 and MCF-7 cancer cells under various metabolic stress conditions.

Scientific Reports · Jul 4, 2023Peer-reviewedCancer Biology

Effect of Water Fluoridation on VM-M3 Tumor Metastasis

T. N. Seyfried, G. M. Mastellone, N. L. Ta, P. Mukherjee, D. C. Lee, J. H. Maurer

This study investigates the effect of water fluoridation on tumor metastasis using VM-M3/Fluc tumor cells in mice, finding no significant impact on metastasis or survival.

bioRxiv · Jun 30, 2023 · PreprintCancer Biology

Ketogenic diet as a metabolic vehicle for enhancing the therapeutic efficacy of mebendazole and devimistat in preclinical high-grade gliomas grown in juvenile mice

P. Mukherjee, J. Maurer, S. A. Stopka, B. Greenwood, J. J. A. Henao, S. Karmacharya, A. Chimento, N. Ta, D. C. Lee, T. Duraj, R. T. Bronson, M. A. Kiebish, T. N. Seyfried

This study shows that combining a ketogenic diet with mebendazole or devimistat improves therapeutic outcomes in preclinical high-grade glioma models in juvenile mice.

bioRxiv · Jun 9, 2023 · PreprintCancer Biology

Residual Complex I activity supports glutamate catabolism and mtSLP via canonical Krebs cycle activity during acute anoxia without OXPHOS

D. Ravasz, D. Bui, S. Nazarian, G. Pallag, N. Karnok, J. Roberts, D. A. Tennant, B. Greenwood, A. Kitayev, C. Hill, T. Komlodi, C. Doerrier, E. Gnaiger, M. A. Kiebish, A. Raska, , C. Chinopoulos

The paper shows that residual Complex I activity sustains glutamate catabolism and mtSLP during acute anoxia by oxidizing NADH with endogenous quinones, bypassing OXPHOS.

bioRxiv · Sep 26, 2022 · PreprintBiochemistry