Nuclear activation in dual-durotaxing cells on a matrix with cell-scale stiffness-heterogeneity
S. Kidoaki, H. Ebata, K. Moriyama, T. Kuboki, Y. Tsuji, R. Sawada, S. Sasaki, T. Okuda, K. Hamano, T. Kawano, A. Yamamoto, K. Kono, K. Tanaka
This study shows that mesenchymal stem cells undergoing dual-durotaxis on stiff micro-patterned gels experience amplified intracellular stress dynamics and chromatin fluctuations, which enhance cellular vigor and maintain stemness.
bioRxiv · Oct 30, 2021 · PreprintBiophysics