S. H. Parekh

Collagen organization and structure in FLBN5-/- mice using label-free microscopy: implications for pelvic organ prolapse

This study uses label-free microscopy to analyze collagen structure in FBLN5-/- mice, finding isotropic collagen and reduced alignment in prolapsed cervix.

Protein-specific crowding accelerates aging in phase-separated droplets

This study shows that PEG affects phase-separated droplets differently depending on the protein, accelerating Nup98 maturation but stabilizing BSA droplets.

Lipid droplets as substrates for protein phase separation

This study shows that intrinsically disordered proteins can undergo phase separation on lipid droplet surfaces, forming liquid-like protein-rich phases.

A solid beta-sheet structure is formed at the surface of FUS liquid droplets during aging

This study investigates FUS liquid droplet maturation, revealing a solid beta-sheet surface layer that forms during aging, with RNA inhibiting this process.

Engineering Alignment has Mixed Effects on hiPSC-CM Maturation

This paper shows engineered alignment improves hiPSC-CM maturity by affecting electrochemical coupling and mitochondrial morphology, but also notes metabolic shifts during differentiation.

Comparing lipid remodeling in mouse adipose and liver tissue with quantitative Raman microscopy

This study compares lipid remodeling in mouse adipose and liver tissue after one week of high-fat diet intervention using quantitative Raman microscopy, finding faster lipid changes in brown adipose tissue.

Biomechanical dependence of SARS-CoV-2 infections

This study investigates how lung biomechanical changes with age affect SARS-CoV-2 infection rates using hydrogels and fiber matrices, finding higher infection rates on softer scaffolds resembling younger lungs.

Quantification of iPSC-derived vascular networks in novel phototunable angiogenic hydrogels

This paper develops a tunable hydrogel for iPSC-derived vascular network formation and shows that stiffness modulation affects vascular growth.

A Whole Blood Thrombus Mimic: Constitutive Behavior Under Simple Shear

This paper develops an in-vitro thrombus mimic from whole blood and tests its mechanical behavior under simple shear, finding strain-stiffening and the Ogden model provides the best fit.

Effect of shear and tensile loading on fibrin molecular structure revealed by coherent Raman microscopy

This study uses coherent Raman microscopy to examine how shear and tensile forces affect fibrin molecular structure at different strain levels.

Toward understanding thrombus fracture: Dissipative phenomena of whole blood clots

This study identifies and quantifies dissipative mechanisms in whole blood clots under various mechanical tests, revealing phenomena similar to hydrogels that are critical for understanding thrombus fracture.

Tension causes structural unfolding of intracellular intermediate filaments

The paper uses Raman imaging to show that intracellular vimentin unfolds under cellular tension, indicating IFs act as force sensors.

Molecular control of interfacial protein structure on graphene-based substrates steers cell fate

This study shows how altering graphene substrates' surface chemistry affects fibronectin structure, which in turn influences stem cell behavior and bone differentiation.

Inserting small molecules across membrane mixtures: Insight from the potential of mean force

This paper uses potential of mean force calculations and simulations to study how small molecules affect membrane phase separation, finding that insertion location determines their effectiveness.