Author

T. Shibue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

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Organism:human· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. Vazquez· 3 shared A. Jones· 2 shared A. Tsherniak· 2 shared A. Warren· 2 shared J. M. McFarland· 2 shared M. Ghandi· 2 shared A. Apffel· 1 shared A. D'Andrea· 1 shared

Activity by Year

2018-2020 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

F. Vazquez

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3 papers

Recent·Most cited

Global computational alignment of tumor and cell line transcriptional profiles

A. Warren, A. Jones, T. Shibue, W. C. Hahn, J. S. Boehm, F. Vazquez, A. Tsherniak, J. M. McFarland

The paper develops an unsupervised alignment method to compare tumor and cell line transcriptional profiles, revealing differences in similarity across cancer types and identifying cell lines with distinct transcriptional states.

bioRxiv · Mar 25, 2020Cancer Biology

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

J. M. McFarland, B. R. Paolella, A. Warren, K. Geiger-Schuller, T. Shibue, M. Rothberg, O. Kuksenko, A. Jones, E. Chambers, D. Dionne, S. Bender, B. M. Wolpin, M. Ghandi, I. Tirosh, O. Rozenblatt-Rosen, , A. Tsherniak

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

bioRxiv · Dec 8, 2019Cancer Biology

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

E. Chan, T. Shibue, J. McFarland, B. Gaeta, J. McPartlan, M. Ghandi, J. B. Liu, J.-B. Lazaro, N. Dumont, A. Gonzalez, A. Apffel, S. O. Ali, L. Leung, E. Roberts, E. Rizvochenko, , A. J. Bass

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.

bioRxiv · Dec 21, 2018Cancer Biology