Author

N. Dumont

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

F. Vazquez· 3 shared A. Gonzalez· 2 shared J. G. Doench· 2 shared J. Laganiere· 2 shared J. M. McFarland· 2 shared J. S. Boehm· 2 shared T. R. Golub· 2 shared Y. Doyon· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

F. Vazquez

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pharmacological control of CAR T cells through CRISPR-driven rapamycin resistance

S. Levesque, G. Carleton, V. Duque, C. Goupil, J.-P. Fiset, S. Villeneuve, E. Normandeau, G. Morin, N. Dumont, B. H. Nelson, J. Laganiere, B. Boyle, J. J. Lum, Y. Doyon

This study develops a CRISPR-based method to create rapamycin-resistant CAR-T cells, enabling pharmacological control of their activity in cancer therapy.

bioRxiv · Sep 14, 2023 · PreprintCancer Biology

Accessory-cell-free differentiation of hematopoietic stem and progenitor cells into mature red blood cells

Y. Boccacci, N. Dumont, Y. Doyon, J. Laganiere

This paper describes the differentiation of hematopoietic stem and progenitor cells into mature red blood cells without accessory cells or animal components, enabling storage for up to 42 days.

bioRxiv · Sep 14, 2022Cell Biology

Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1.

T. Conte, G. D. Bishop, Z. Orfi, I. Mokhtari, A. Deprez, M.-P. Roussel, I. Cote, O. Pellerito, D. Maggiorani, B. Benabdallah, S. Leclerc, L. Feulner, J. Mathieu, C. Gagnon, G. Andelfinger, , N. Dumont

This study identifies a senescent molecular signature in DM1 myogenic cells and shows that senolytics reduce SASP and restore myogenesis.

bioRxiv · Jun 22, 2022 · PreprintCell Biology

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

D. P. Bondeson, B. R. Paolella, A. Asfaw, M. Rothberg, T. Skipper, C. Langan, A. Gonzalez, L. Surface, K. Ito, M. Kazachkova, W. N. Colgan, A. Warren, J. Dempster, J. M. Krill-Burger, M. Ericcson, , T. R. Golub

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

bioRxiv · Oct 16, 2020Cancer Biology

Non-oncology drugs are a source of previously unappreciated anti-cancer activity

S. M. Corsello, R. T. Nagari, R. D. Spangler, J. Rossen, M. Kocak, J. G. Bryan, R. Humeidi, D. Peck, X. Wu, A. A. Tang, V. M. Wang, S. A. Bender, E. Lemire, R. Narayan, P. Montgomery, , T. R. Golub

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.

bioRxiv · Aug 9, 2019Cancer Biology

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

E. Chan, T. Shibue, J. McFarland, B. Gaeta, J. McPartlan, M. Ghandi, J. B. Liu, J.-B. Lazaro, N. Dumont, A. Gonzalez, A. Apffel, S. O. Ali, L. Leung, E. Roberts, E. Rizvochenko, , A. J. Bass

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.

bioRxiv · Dec 21, 2018Cancer Biology