Author

M. Rothberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Warren· 2 shared B. R. Paolella· 2 shared F. Vazquez· 2 shared J. M. McFarland· 2 shared T. R. Golub· 2 shared A. Asfaw· 1 shared A. Gonzalez· 1 shared A. J. Aguirre· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

A. Warren

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Author profile →

2 papers

Recent·Most cited

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

D. P. Bondeson, B. R. Paolella, A. Asfaw, M. Rothberg, T. Skipper, C. Langan, A. Gonzalez, L. Surface, K. Ito, M. Kazachkova, W. N. Colgan, A. Warren, J. Dempster, J. M. Krill-Burger, M. Ericcson, , T. R. Golub

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

bioRxiv · Oct 16, 2020Cancer Biology

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

J. M. McFarland, B. R. Paolella, A. Warren, K. Geiger-Schuller, T. Shibue, M. Rothberg, O. Kuksenko, A. Jones, E. Chambers, D. Dionne, S. Bender, B. M. Wolpin, M. Ghandi, I. Tirosh, O. Rozenblatt-Rosen, , A. Tsherniak

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

bioRxiv · Dec 8, 2019Cancer Biology