K. Geiger-Schuller

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

A collection of programs for one-dimensional Ising analysis of linear repeat proteins with point substitutions

The paper presents programs for analyzing the thermodynamics of linear repeat proteins using a 1D Ising model to study folding and mutation effects.

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

Functional instability allows access to DNA in longer Transcription Activator-Like Effector (TALE) arrays.

The paper examines DNA binding kinetics of TALE arrays using single molecule microscopy and deterministic modeling, revealing functional instability due to conformational heterogeneity.