Author

T. Somerville

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. Vakoc· 3 shared D. Tuveson· 2 shared Y. Xu· 2 shared A. D. Borowsky· 1 shared A. Kolarzyk· 1 shared A. Lazenby· 1 shared C. E. Corless· 1 shared C. Tonelli· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

C. Vakoc

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Engrailed-1 Promotes Pancreatic Cancer Metastasis

J. Xu, J. S. Roe, E. Lee, C. Tonelli, T. Somerville, M. Yao, J. Milazzo, H. Tiriac, A. Kolarzyk, E. Lee, J. Grem, A. Lazenby, J. Grunkemeyer, M. Hollingsworth, A. D. Borowsky, , C.-i. Hwang

This study shows EN1 promotes pancreatic cancer metastasis by repressing target genes and enhancing mesenchymal properties.

bioRxiv · Apr 10, 2023 · PreprintCancer Biology

ZBED2 is an antagonist of Interferon Regulatory Factor 1 and modulates cell identity in pancreatic cancer

T. Somerville, Y. Xu, X. Wu, C. Vakoc

This study identifies ZBED2 as a transcriptional repressor that antagonizes IRF1 to modulate cell identity and suppress interferon response in pancreatic cancer.

bioRxiv · Dec 6, 2019Cancer Biology

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

T. Somerville, G. Biffi, J. Dassler-Plenker, K. Miyabayashi, Y. Xu, D. Maia-Silva, O. Klingbeil, O. Demerdash, M. Egeblad, D. Tuveson, C. Vakoc

This study shows that squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by converting pancreatic stellate cells into inflammatory CAFs via TP63-dependent mechanisms.

bioRxiv · Nov 6, 2019Cancer Biology

Use of a corneal impression membrane for the detection of Herpes Simplex Virus type-1

M. Brunner, T. Somerville, C. E. Corless, J. Myneni, T. Rajhbeharrysingh, S. Tiew, T. Neal, S. B. Kaye

This study compares corneal impression membranes (CIMs) and swabs for HSV-1 detection in suspected HSK, finding CIMs more effective.

bioRxiv · Oct 29, 2018Microbiology