Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
E. G. Lloyd, M. Jihad, J. S. Manansala, W. Li, P. S. Cheng, S. P. Teles, G. Mucciolo, J. A. Henriquez, S. Ashworth, W. Luo, S. Harish, P. M. Johnson, L. Veghini, M. Zaccaria, R. Brais, , G. Biffi
This study shows that SMAD4 and KRAS mutations influence stromal composition and therapeutic response in pancreatic cancer models.
bioRxiv · Apr 28, 2024Cancer Biology
J. Stockis, T. Yip, S. Raghunathan, C. Garcia, S. Lee, C. Simpson, S. Silvain, M. J. Schuijs, J. Araos, S. Png, G. Raddi, O. Bricard, T. Y. So, S. Mack, P. Papadopoulos, , T. Y. F. Halim
This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.
bioRxiv · Feb 15, 2024 · PreprintImmunology
G. Mucciolo, J. Araos Henriquez, S. Pinto Teles, J. S. Manansala, M. Jihad, W. Li, E. G. Lloyd, P. S. W. Cheng, G. Biffi
This study identifies ERBB signaling in myofibroblastic CAFs as a driver of local PDAC metastasis and suggests its potential as a therapeutic target.
Cancer Cell · Jan 1, 2024Peer-reviewedCancer Biology
L. Veghini, D. Pasini, P. Delfino, V. Corbo, E. Fiorini, F. Lupo, M. Bevere, C. Luchini, R. T. Lawlor, A. Scarpa, P. F.-Y. Cheung, J. T. Siveke, C. Vicentini, D. Filippini, S. L. D'Agosto, , R. Fang
This study identifies MAPK signalling as defining fibroblast subtypes in pancreatic cancer, linking MAPKhigh CAFs to poor prognosis and immune evasion.
bioRxiv · Oct 30, 2023Cancer Biology
J. Obacz, R. Nibhani, T. S. Adams, J. C. Schupp, J. A. Valer, N. Veale, G. Aresu, A. S. Coonar, A. Peryt, G. Biffi, N. Kaminski, H. E. Francies, D. Rassl, M. Garnett, R. C. Rintoul, S. J. Marciniak
This study presents a single-cell transcriptomic atlas of human pleura, identifying stromal heterogeneity and informing in vitro models of mesothelioma.
bioRxiv · Dec 3, 2022 · PreprintCancer Biology
T. E. Oni, C. Bautista, J. R. Merrill, J. A. C. M. Goos, K. D. Rivera, K. Miyabayashi, G. Biffi, L. Garcia, D. Plenker, H. Patel, E. Elyada, M. Samaritano, K. H. Yu, D. J. Pappin, M. G. Goggins, , D. A. Tuveson
This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.
bioRxiv · Sep 10, 2020 · PreprintCancer Biology
A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden
The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.
bioRxiv · Mar 9, 2020Cancer Biology
T. Somerville, G. Biffi, J. Dassler-Plenker, K. Miyabayashi, Y. Xu, D. Maia-Silva, O. Klingbeil, O. Demerdash, M. Egeblad, D. Tuveson, C. Vakoc
This study shows that squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by converting pancreatic stellate cells into inflammatory CAFs via TP63-dependent mechanisms.
bioRxiv · Nov 6, 2019Cancer Biology