Author

C.-i. Hwang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Tuveson· 2 shared E. Lee· 2 shared A. Adamo· 1 shared A. D. Borowsky· 1 shared A. Kolarzyk· 1 shared A. Lazenby· 1 shared A. Malinova· 1 shared A. Scarpa· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

D. Tuveson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

E. Lee, S. Archasappawat, K. Ji, J. Pena, V. Fernandez-Vega, R. Gangaraju, N. S. Beesabathuni, M. Kim, Q. Tian, P. Shah, L. Scampavia, T. Spicer, C.-i. Hwang

This study identifies BET inhibition as a potential therapy for BRCA2-deficient pancreatic cancer by showing it enhances autophagy-dependent cell death in these cells.

bioRxiv · May 30, 2023 · PreprintCancer Biology

Engrailed-1 Promotes Pancreatic Cancer Metastasis

J. Xu, J. S. Roe, E. Lee, C. Tonelli, T. Somerville, M. Yao, J. Milazzo, H. Tiriac, A. Kolarzyk, E. Lee, J. Grem, A. Lazenby, J. Grunkemeyer, M. Hollingsworth, A. D. Borowsky, , C.-i. Hwang

This study shows EN1 promotes pancreatic cancer metastasis by repressing target genes and enhancing mesenchymal properties.

bioRxiv · Apr 10, 2023 · PreprintCancer Biology

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

F. Lupo, F. Pezzini, E. Fiorini, A. Adamo, L. Veghini, M. Bevere, C. Frusteri, P. Delfino, S. D'Agosto, S. Andreani, G. Piro, A. Malinova, F. De Sanctis, D. Pasini, R. T. Lawlor, , V. Corbo

This study shows SEMA3A promotes aggressive basal-like PDAC by enhancing metastasis and modulating the tumor microenvironment through macrophage polarization and T cell exclusion.

bioRxiv · Feb 25, 2023Cancer Biology

Genomic heterogeneity in pancreatic cancer organoids and its stability with culture

O. Usman, L. Zhang, G. Xie, H. M. Kocher, C.-i. Hwang, Y. J. Wang, X. F. Mallory, J. Irianto

This study examines genomic heterogeneity and stability in pancreatic cancer organoids using single-cell whole-genome sequencing and transcriptomic analysis.

bioRxiv · Jul 3, 2022Cancer Biology