Author

D. Maia-Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. R. Vakoc· 2 shared A. Alpsoy· 1 shared A. C. Schier· 1 shared C. Vakoc· 1 shared D. A. Tuveson· 1 shared D. J. Taatjes· 1 shared D. Skopelitis· 1 shared D. Tuveson· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

C. R. Vakoc

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3 papers

Recent·Most cited

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma

D. Maia-Silva, A. C. Schier, D. Skopelitis, V. Kechejian, A. Alpsoy, J. Liverpool, D. J. Taatjes, C. R. Vakoc

The paper identifies MED12-p63 interaction as a driver of basal identity in PDAC through genetic screens and biochemical analysis.

bioRxiv · Oct 24, 2023 · PreprintCancer Biology

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma

S. K. Hur, T. D. D. Somerville, X. S. Wu, D. Maia-Silva, O. E. Demerdash, D. A. Tuveson, F. Notta, C. R. Vakoc

This study shows p73 activates basal lineage and ciliogenesis genes in PDAC, suggesting its role in lineage plasticity and tumor progression.

bioRxiv · Apr 20, 2023 · PreprintCancer Biology

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

T. Somerville, G. Biffi, J. Dassler-Plenker, K. Miyabayashi, Y. Xu, D. Maia-Silva, O. Klingbeil, O. Demerdash, M. Egeblad, D. Tuveson, C. Vakoc

This study shows that squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by converting pancreatic stellate cells into inflammatory CAFs via TP63-dependent mechanisms.

bioRxiv · Nov 6, 2019Cancer Biology