Author

T. Spiewla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Jemielity· 3 shared J. Kowalska· 3 shared D. Nowis· 2 shared J. Golab· 2 shared M. Warminski· 2 shared A. Brouze· 1 shared A. Depaix· 1 shared A. Dziembowski· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

J. Jemielity

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Author profile →

3 papers

Recent·Most cited

An MST-based assay reveals new binding preferences of IFIT1 for canonically and non-canonically capped RNAs

T. Spiewla, K. Grab, A. Depaix, K. Ziemkiewicz, M. Warminski, J. Jemielity, J. Kowalska

This study develops an MST-based assay to assess IFIT1 binding to various capped RNAs, revealing new preferences for canonical and non-canonical RNA caps.

bioRxiv · May 10, 2024Biochemistry

Trinucleotide mRNA cap analog N6-benzylated at the site of posttranscriptional m6Am mark facilitates mRNA purification and confers superior translational properties in vitro and in vivo

M. Warminski, E. Trepkowska, M. Smietanski, P. J. Sikorski, M. R. Baranowski, M. Bednarczyk, H. Kedzierska, B. Majewski, A. Mamot, D. Papiernik, A. Popielec, R. Serwa, B. A. Shimanski, P. Sklepkiewicz, M. Sklucka, , J. Kowalska

This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.

bioRxiv · Nov 10, 2023 · PreprintBiochemistry

SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

P. S. Krawczyk, O. Gewartowska, M. Mazur, W. Orzel, K. Matylla-Kulinska, S. Jelen, P. Turowski, T. Spiewla, B. Tarkowski, A. Tudek, A. Brouze, A. Wesolowska, D. Nowis, J. Golab, J. Kowalska, , S. Mroczek

This study shows that SARS-CoV-2 mRNA vaccines are re-adenylated in vivo, increasing antigen production and immune response in macrophages.

bioRxiv · Dec 1, 2022 · PreprintImmunology