Targeting NRP1 with EG00229 induces neurovascular permeability
S. Dragoni, J. T. Brash, A. Fantin, C. Burridge, L. Denti, P. Turowski, C. Ruhrberg
This study shows that EG00229, designed to inhibit VEGF-NRP1 interaction, paradoxically increases vascular leakage by activating NRP1-dependent signaling pathways.
bioRxiv · Nov 7, 2023 · PreprintPhysiology