T. Tagawa

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

This study identifies IFN-induced circRNAs that resist herpesvirus host shutoff and inhibit lytic infection across multiple herpesvirus subfamilies.

A virus-induced circular RNA maintains latent infection of Kaposi sarcoma herpesvirus

This study identifies a virus-induced circular RNA, hsa_circ_0001400, that promotes KSHV latency by inhibiting lytic replication and enhancing cell survival.

Transcriptional analysis identifies overlapping and tissue-distinct profiles between Kaposi sarcoma tumors of the skin and gastrointestinal tract

This study compares gene expression in Kaposi sarcoma tumors from skin and gastrointestinal tracts, identifying distinct and overlapping patterns of viral and host gene expression.

Multiple viral microRNAs regulate interferon release and signaling early during infection with Epstein-Barr virus

This study identifies EBV miRNAs that regulate type I interferon responses in B cells and pDCs during early infection, dampening IFN- secretion.

Micro RNAs are minor constituents of extracellular vesicles and are hardly delivered to target cells

This study investigates whether extracellular vesicles (EVs) deliver microRNAs to target cells and found that miRNAs are not effectively delivered or functional.

BZLF1 interacts with the chromatin remodeler INO80 promoting escape from latent infections with Epstein-Barr virus

This study identifies BZLF1's role in reactivating Epstein-Barr virus by interacting with the chromatin remodeler INO80 to overcome epigenetic silencing.