Author

L. T. Krug

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

C. H. Hogan· 3 shared J. C. Forrest· 3 shared J. M. Ziegelbauer· 3 shared Q. Dong· 3 shared V. Kirillov· 3 shared X. Li· 3 shared C. Khairallah· 2 shared D. G. Oldenburg· 2 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

C. H. Hogan

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Author profile →

7 papers

Recent·Most cited

Replication-dead gammaherpesvirus vaccine protects against acute replication, reactivation from latency, and lethal challenge in mice

W. A. Bland, S. M. Owens, K. McEvoy, C. H. Hogan, L. Boccuzzi, V. Kirillov, C. Khairallah, B. S. Sheridan, J. C. Forrest, L. T. Krug

This paper develops a replication-dead gammaherpesvirus vaccine that protects mice from acute replication, reactivation, and lethal disease caused by wild-type virus.

bioRxiv · Sep 26, 2023Microbiology

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

S. E. Dremel, T. Tagawa, V. N. Koparde, J. H. Arbuckle, T. M. Kristie, L. T. Krug, J. M. Ziegelbauer

This study identifies IFN-induced circRNAs that resist herpesvirus host shutoff and inhibit lytic infection across multiple herpesvirus subfamilies.

bioRxiv · Sep 7, 2023Microbiology

Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues

K. R. Smith, S. Paul, Q. Dong, O. Anannya, D. G. Oldenburg, J. C. Forrest, K. M. McBride, L. T. Krug

This paper identifies a non-enzymatic role for murine gammaherpesvirus 68 vUNG in forming a complex with viral DNA replication factors, independent of its catalytic activity.

bioRxiv · May 19, 2023Microbiology

B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model

C. H. Hogan, S. M. Owens, G. V. Reynoso, V. Kirillov, T. J. Meyer, M. A. Zelazowska, B. Liu, X. Li, A. Chikhalya, Q. Dong, C. Khairallah, N. C. Reich, B. Sheridan, K. M. McBride, P. Hearing, , L. T. Krug

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology

Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses

S. E. Dremel, V. N. Koparde, J. H. Arbuckle, C. H. Hogan, T. M. Kristie, L. T. Krug, N. K. Conrad, J. M. Ziegelbauer

This study identifies noncanonical circRNA biogenesis driven by herpesviruses, showing viral circRNAs resist spliceosome inhibition and are enriched during lytic infection.

bioRxiv · Jul 8, 2022Microbiology

Transcriptional analysis identifies overlapping and tissue-distinct profiles between Kaposi sarcoma tumors of the skin and gastrointestinal tract

R. Ramaswami, T. Tagawa, G. Mahesh, A. Serquina, V. Koparde, K. Lurain, S. Dremel, X. Li, A. Mungale, A. Beran, Z. Weaver Ohler, L. Bassel, A. Warner, R. Mangusan, A. Widell, , J. M. Ziegelbauer

This study compares gene expression in Kaposi sarcoma tumors from skin and gastrointestinal tracts, identifying distinct and overlapping patterns of viral and host gene expression.

bioRxiv · Mar 18, 2022 · PreprintMicrobiology

IKKalpha-Mediated Non-canonical NF-kappaB Signaling is Required to Support Murine Gammaherpesvirus 68 Latency In Vivo

B. Cieniewicz, V. Kirillov, I. Daher, X. Li, D. G. Oldenburg, Q. Dong, J. A. Bettke, K. B. Marcu, L. T. Krug

This study shows that non-canonical NF-kappaB signaling via IKKalpha is essential for MHV68 latency in mice, but not for viral replication or reactivation in all cell types.

bioRxiv · Jan 5, 2022Microbiology