Author

O. T. Keppler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2

Frequent Co-Authors

C. Scherer· 2 shared C. Schneider· 2 shared D. Thomas· 2 shared G. Geisslinger· 2 shared J. Cinatl· 2 shared K. Stark· 2 shared M. Albanese· 2 shared M. Muenchhoff· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

C. Scherer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

ediTONSIL: Activation-Neutral Gene Editing of CD4 T cells in Human ex Vivo Tonsil Cultures

K. Morath, L. Sadhu, G. Dyckhoff, M. Gapp, O. T. Keppler, O. T. Fackler

The paper introduces ediTONSIL, a method to edit resting CD4 T cells from human tonsil tissue without activation, achieving >90% knockout efficacy and preserving cell function.

bioRxiv · Aug 21, 2023 · PreprintImmunology

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

T. Rothenburger, D. Thomas, Y. Schreiber, P. R. Wratil, T. Pflantz, K. Knecht, K. Digianantonio, J. Temple, C. Schneider, H.-M. Baldauf, K.-M. McLaughlin, F. Rothweiler, B. Bilen, S. Farmand, D. Bojkova, , J. Cinatl

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

bioRxiv · Jul 19, 2021Pharmacology & Toxicology

Impaired function and delayed regeneration of dendritic cells in COVID-19

E. Winheim, L. Rinke, K. Lutz, A. Reischer, A. Leutbecher, L. Wolfram, L. Rausch, J. Kranich, P. R. Wratil, J. Huber, D. Baumjohann, S. Rothenfusser, J. Hellmuth, C. Scherer, M. Muenchhoff, , A. B. Krug

This study examines dendritic cell and monocyte function and regeneration in COVID-19 patients, finding persistent reductions and functional impairments linked to disease severity.

bioRxiv · May 26, 2021 · PreprintImmunology

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

K. Pekayvaz, A. Leunig, R. Kaiser, S. Brambs, M. Joppich, A. Janjic, O. Popp, V. Polewka, L. E. Wange, C. Gold, M. Kirchner, M. Muenchhoff, J. C. Hellmuth, C. Scherer, T. Eser, , L. Nicolai

This study identifies an early interferon-stimulated gene (ISG) upregulation as a protective immune signature in non-pneumonic SARS-CoV-2 infection, preventing progression to pneumonia.

bioRxiv · Feb 3, 2021Immunology

Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection

E. Akidil, M. Albanese, A. Buschle, A. Ruhle, O. T. Keppler, W. Hammerschmidt

bioRxiv · Oct 16, 2020Immunology

Micro RNAs are minor constituents of extracellular vesicles and are hardly delivered to target cells

M. Albanese, Y.-F. A. Chen, C. Huels, K. Gaertner, T. Tagawa, E. Mejias-Perez, O. T. Keppler, C. Goebel, R. Zeidler, M. Shein, A. K. Schuetz, W. Hammerschmidt

This study investigates whether extracellular vesicles (EVs) deliver microRNAs to target cells and found that miRNAs are not effectively delivered or functional.

bioRxiv · May 20, 2020Cell Biology

Histone deacetylase inhibitors butyrate and bufexamac inhibit de novo HIV-1 infection in CD4 T-cells

C. Schölz, L. Chen, A. Zutz, O. T. Keppler, J. Philippou-Massier, H. Blum, T. Liebner, C. Choudhary

This study shows that HDAC inhibitors butyrate and bufexamac inhibit de novo HIV-1 infection in CD4 T-cells without reactivating latent virus.

bioRxiv · Apr 29, 2020 · PreprintMicrobiology

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

K. M. Knecht, O. Buzovetsky, C. Schneider, D. Thomas, V. Srikanth, F. Tofoleanu, K. Reiss, N. Ferreiros, G. Geisslinger, V. S. Batista, X. Ji, J. Cinatl, O. T. Keppler, Y. Xiong

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

bioRxiv · Apr 6, 2018Biochemistry