Author

T. W. Kan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. Rao· 3 shared T. Mahmoudi· 3 shared R.-J. Palstra· 2 shared S. Romal· 2 shared A. Antanaviciute· 1 shared A. Bazrafshan· 1 shared A. Goodspeed· 1 shared A. Gorska· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

S. Rao

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease

J. D. Windster, L. E. Kuil, N. J. M. Kakiailatu, A. Antanaviciute, A. Sacchetti, K. C. MacKenzie, J. Peulen-Zink, T. W. Kan, E. Bindels, E. de Pater, M. Doukas, S. Yousefi, T. S. Barakat, C. J. H. M. Meeussen, P. C. E. J. Sloots, , M. Alves

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

bioRxiv · Sep 26, 2023Pathology

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

R. Crespo, E. Ne, J. Reinders, J. I. J. Meier, C. Li, S. Jansen, A. Gorska, S. Kocer, T. W. Kan, W. Doff, D. Dekkers, J. Demmers, R. J. Palstra, S. Rao, T. Mahmoudi

This study identifies PCID2 as a novel HIV-1 latency-promoting factor that represses transcription and dysregulates viral RNA processing through its role in the TREX2 complex.

bioRxiv · Sep 21, 2023Microbiology

SQuHIVLa: A novel assay for Specific Quantification of inducible HIV-1 reservoir by LAMP

T. Hossain, C. Lungu, S. de Schrijver, M. Kuali, S. Rao, A. Ngubane, T. W. Kan, R.-J. Palstra, P. Madlala, T. Ndung'u, T. Mahmoudi

SQuHIVLa quantifies inducible HIV-1 reservoirs in CD4+ T cells using a sensitive and specific RT-LAMP assay, showing high throughput and scalability.

bioRxiv · Jul 14, 2023 · PreprintMicrobiology

NPEPPS is a novel and druggable driver of platinum resistance

R. T. Jones, M. Scholtes, A. Goodspeed, M. M. Akbarzadeh, S. Mohapatra, L. E. Feldman, H. Vekony, A. Jean, C. B. Tilton, M. V. Orman, S. Romal, C. Deiter, T. W. Kan, N. Xander, S. Araki, , J. C. Costello

This study identifies NPEPPS as a driver of cisplatin resistance in bladder cancer and shows its inhibition can enhance cisplatin efficacy in preclinical models.

bioRxiv · Mar 4, 2021 · PreprintCancer Biology

Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma

E. De Crignis, S. Romal, F. Carofiglio, P. Moulos, M. M. A. Verstegen, M. M. Khalid, F. Pourfarzad, S. Rao, A. Bazrafshan, C. Koutsothanassis, H. Gehart, T. W. Kan, R.-J. Palstra, C. Boucher, J. IJzermans, , T. Mahmoudi

This paper establishes human liver organoids as a model for HBV infection and HCC, showing they support viral replication, produce infectious HBV, and exhibit cancer-related gene signatures.

bioRxiv · Nov 11, 2020Cancer Biology