H. Laubli

Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer

This study uses multimodal single-cell profiling to analyze T cell specificity and reactivity in lung cancer patients, identifying tumor- and virus-reactive T cells and their functional states.

Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker

This paper develops a CAR T cell therapy that secretes a CD47 blocker to enhance anti-EGFRvIII efficacy against glioblastoma by modulating the tumor microenvironment.

The Siglec-sialic acid-axis is a target for innate immunotherapy of glioblastoma

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis

The paper shows that the tumor extracellular matrix educates macrophages to adopt a phenotype seen in ovarian cancer metastasis, affecting T cell function and immune regulation.

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

This study shows hyperglycemia promotes cancer immune evasion by increasing O-GlcNAcylation in tumor-associated macrophages, shifting their polarization to a pro-tumorigenic M2-like phenotype.

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma