Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy
Qilin Guo, Davide Gobbo, Na Zhao, Hong Zhang, Nana-Oye Awuku, Qing Liu, Li‐Pao Fang, Tanja M. Gampfer, Markus Robert Meyer, Renping Zhao, Xianshu Bai, Shan Bian, Anja Scheller, Frank Kirchhoff, Wenhui Huang
This study shows that adenosine triggers early astrocyte reactivity in sepsis, leading to microglial activation and SAE pathogenesis.
Nature Communications · Jul 27, 2024Peer-reviewedNeuroscience