Frank Kirchhoff

This study shows GABAB receptors have dual roles in oligodendrocyte function and immune modulation in experimental MS, with baclofen showing therapeutic potential in reducing disease severity and promoting remyelination.

This study shows that cannabidiol (CBD) reverses memory deficits and neuroinflammation in a mouse model of schizophrenia by targeting 5-HT1A and CB2 receptors.

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

This study shows that adenosine triggers early astrocyte reactivity in sepsis, leading to microglial activation and SAE pathogenesis.

This study shows that removing GABAB receptors from oligodendrocyte precursor cells in mice protects against demyelination in spinal cord injury models.

The paper identifies a shared inflammatory glial cell signature after brain injury using spatial and single-cell transcriptomics in mice, showing common injury-regulated genes across astrocytes, microglia, and oligodendrocyte precursor cells.

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

The paper identifies a subset of oligodendrocyte precursor cells (OPCs) that lack Olig2 expression, which is influenced by brain injuries and complex motor learning.

This study uses in vivo imaging to show that cannabidiol reduces microglial activation and protects neurons in the subacute phase of stroke.

This study develops a specific antibody and Cre-dependent conditional KO mouse to detect and delete the Sigma-1 receptor in specific cell types in vivo, revealing its widespread expression in neurons and glial cells.

The paper introduces two algorithms for detecting and analyzing fluorescent signal fluctuations, along with an interactive tool for their application.

The paper identifies a GABA/TNF-related cytokine-mediated communication pathway between interneurons and oligodendrocyte precursor cells that affects myelination and cognitive behavior.

This study shows that dysfunction in grey matter NG2 glial cells affects neuronal plasticity and behavior, specifically impairing long-term potentiation but improving spatial memory.

This paper introduces a multi-threshold event detection algorithm for analyzing Ca2+ activity patterns across different experimental conditions and organisms.

This study shows that Alix is required for activity-dependent bulk endocytosis at brain synapses, and its absence reduces seizure severity in mice.