Xianshu Bai

Dual role of GABAB receptor in oligodendrocyte function and immune modulation in experimental multiple sclerosis

This study shows GABAB receptors have dual roles in oligodendrocyte function and immune modulation in experimental MS, with baclofen showing therapeutic potential in reducing disease severity and promoting remyelination.

Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative disease

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy

This study shows that adenosine triggers early astrocyte reactivity in sepsis, leading to microglial activation and SAE pathogenesis.

Genetic ablation of GABAB receptors from oligodendrocyte precursor cells protects against demyelination in the mouse spinal cord

This study shows that removing GABAB receptors from oligodendrocyte precursor cells in mice protects against demyelination in spinal cord injury models.

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex

The paper identifies a shared inflammatory glial cell signature after brain injury using spatial and single-cell transcriptomics in mice, showing common injury-regulated genes across astrocytes, microglia, and oligodendrocyte precursor cells.

After traumatic brain injury oligodendrocytes regain a plastic phenotype and can become astrocytes

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

Brain injuries and complex motor learning suppress Olig2 in a subpopulation of oligodendrocyte precursor cells

The paper identifies a subset of oligodendrocyte precursor cells (OPCs) that lack Olig2 expression, which is influenced by brain injuries and complex motor learning.

Novel algorithms for improved detection and analysis of fluorescent signal fluctuations

The paper introduces two algorithms for detecting and analyzing fluorescent signal fluctuations, along with an interactive tool for their application.

Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects cognitive behavior

The paper identifies a GABA/TNF-related cytokine-mediated communication pathway between interneurons and oligodendrocyte precursor cells that affects myelination and cognitive behavior.