Wenhui Huang

This study identifies impaired astrocytic Cx43 syncytial networks in the lateral habenula as a driver of adolescent stress-induced depression through disrupted synaptic connectivity and neuronal function.

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

This study shows that adenosine triggers early astrocyte reactivity in sepsis, leading to microglial activation and SAE pathogenesis.

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

The paper identifies a subset of oligodendrocyte precursor cells (OPCs) that lack Olig2 expression, which is influenced by brain injuries and complex motor learning.

This study develops a specific antibody and Cre-dependent conditional KO mouse to detect and delete the Sigma-1 receptor in specific cell types in vivo, revealing its widespread expression in neurons and glial cells.

The paper identifies a GABA/TNF-related cytokine-mediated communication pathway between interneurons and oligodendrocyte precursor cells that affects myelination and cognitive behavior.

This study shows that dysfunction in grey matter NG2 glial cells affects neuronal plasticity and behavior, specifically impairing long-term potentiation but improving spatial memory.

This study shows that amyloid β oligomers constrict human capillaries via pericyte signaling, reducing blood flow and contributing to Alzheimer’s disease pathology.