Shan Bian

Genome-Wide Investigation of Transcription Factor Occupancy and Dynamics Using cFOOT-seq

The paper introduces cFOOT-seq, a method for high-resolution, quantitative detection of TF occupancy across the genome, and demonstrates its application in analyzing TF dynamics and dependencies.

Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative disease

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

ImSpiRE: Image feature-aided spatial resolution enhancement method

ImSpiRE enhances spatial transcriptomic resolution using image features and optimal transport to improve subspot-level resolution and discover tissue domains and signaling patterns.

Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy

This study shows that adenosine triggers early astrocyte reactivity in sepsis, leading to microglial activation and SAE pathogenesis.

After traumatic brain injury oligodendrocytes regain a plastic phenotype and can become astrocytes

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

Fused dorsal-ventral cerebral organoids model human cortical interneuron migration

This paper describes a method to model human cortical interneuron migration using fused dorsal-ventral cerebral organoids and demonstrates directional migration inhibited by AMD3100.