Author

Hongyan Wang

Fudan UniversityORCID 0000-0002-9422-5264Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Chengdong ZhangiD· 2 shared Dong LiuiD· 2 shared Feng LaniD· 2 shared Linghui HouiD· 2 shared Tao Qi· 2 shared Yongming WangiD· 2 shared Binbin LiiD· 1 shared Daqi Wang· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Chengdong ZhangORCID

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4 papers

Recent·Most cited

Upregulation of TBX1 by genetic variants are associated with human congenital heart disease

Li-Wei Yu, Binbin Li, Hongyan Wang

This study identifies a genetic variant in TBX1 associated with congenital heart disease and shows it increases TBX1 promoter activity and risk.

medRxiv · Jul 21, 2021 · PreprintGenetic & Genomic Medicine

BEdeepoff: an in silico tool for off-target prediction of ABE and CBE base editors

Chengdong Zhang, Daqi Wang, Tao Qi, Yuening Zhang, Linghui Hou, Feng Lan, Jingcheng Yang, Sang‐Ging Ong, Hongyan Wang, Leming M. Shi, Yongming Wang

BEdeepoff predicts off-target editing efficiencies for ABE and CBE base editors using deep learning models trained on high-throughput screening data.

bioRxiv · Mar 14, 2021 · PreprintBioinformatics

Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity

Ziying Hu, Chengdong Zhang, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, Linghui Hou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, Hongyan Wang, , Yongming Wang

The paper identifies and engineers a compact SlugCas9 variant with broad targeting range, high specificity, and activity for genome editing.

Nucleic Acids Research · Feb 23, 2021Peer-reviewedGenetics

MECP2 duplication and mutations impair NSCs differentiation via miR-197 regulated ADAM10

Yumeng Wang, Yufang Zheng, Si-Yu Yang, Yang Zhang-min, Linna Zhang, Yan-Qin He, Xiaohong Gong, Dong Liu, Richard H. Finnell, Zilong Qiu, Yasong Du, Hongyan Wang

This study shows that MECP2 duplication and mutations impair neural stem cell differentiation through miR-197 regulation of ADAM10 and NOTCH signaling.

bioRxiv · May 2, 2018 · PreprintDevelopmental Biology