Loss of Vpr-driven TRAIL-R2 expression protects HIV-infected cells from non-canonical NK cell TRAIL attack
Paula E. Grasberger, Abigail Sondrini, Nicole C. Glidden, Amanda Modica, Natalie Pushlar, Seden Bedir, Tara Bromfield, Sheldon Gentling, Komal Cheema, Alper Küçükural, Milena Ozdemir, Maria L. Zapp, Alberto Bosque, Louise Leyre, Aaron Shulkin, , Kiera Clayton
The paper shows HIV uses Vpr to increase TRAIL-R2 expression in CD4+ T cells, which enhances NK cell killing through non-canonical TRAIL signaling.
bioRxiv · Apr 19, 2026 · PreprintImmunology