Philip R. Gafken

Tumor cell methylation of KRASG12V epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.

The paper identifies Muskelin as a substrate adaptor for the Drosophila CTLH E3 ligase, showing how it regulates the degradation of RNA-binding proteins during the maternal-to-zygotic transition.

The paper shows that G1 phase length regulates H3K27me3 levels in stem and tumor cells, with longer G1 increasing and shorter G1 decreasing H3K27me3.

The paper quantifies proteomic changes in DUX4-expressing cells, revealing post-transcriptional dysregulation in FSHD pathology.