Author

Shwetha Mureli

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Philip D. GreenbergiD· 2 shared Tijana MartinoviD· 2 shared Alexander MarsoniD· 1 shared Angie Vazquez· 1 shared Ashley M. TheleniD· 1 shared Aude G. ChapuisiD· 1 shared Brian Rudolph ShyiD· 1 shared Camille FouassieriD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Philip D. GreenbergORCID

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2 papers

Recent·Most cited

Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal Leukoencephalopathy

Sasha Gupta, Tijana Martinov, Ashley M. Thelen, Megumi Sunahara, Shwetha Mureli, Angie Vazquez, Josiah Gerdts, Ravi Dandekar, Irene C. M. Cortese, Camille Fouassier, Elaine V. Schanzer, Fyodor D. Urnov, Alexander Marson, Brian Rudolph Shy, Philip D. Greenberg, Michael R. Wilson

The paper identifies JCV VP1 epitopes recognized by HLA-A2 and isolates TCRs that recognize these epitopes, showing cytotoxic activity against infected cells.

bioRxiv · Nov 4, 2024 · PreprintNeuroscience

Overcoming immune evasion from post-translational modification of a mutant KRAS epitope to achieve TCR-T cell-mediated antitumor activity

Jihoon William Lee, Emily Y. Chen, Taylor Hu, Rachel Perret, Mary E. Chaffee, Tijana Martinov, Shwetha Mureli, Clara McCurdy, Lisa Anne Jones, Philip R. Gafken, Pritha Chanana, Yapeng Su, Aude G. Chapuis, Philip H Bradley, Thomas M. Schmitt, Philip D. Greenberg

Tumor cell methylation of KRASG12V epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.

bioRxiv · Sep 18, 2024 · PreprintImmunology