Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice
Elika Z. Moallem, Ronald C. Bruntz, MaKayla F. Cox, Leke Bytyqi, Taylor K Roberts, Samir P. Patel, Teresa Macheda, Kelly N. Roberts, Emma K. Higgins, Ramon C. Sun, Matthew S. Gentry, Patrick G. Sullivan, Lance A. Johnson, Adam D. Bachstetter
The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.
bioRxiv · Oct 6, 2026 · PreprintNeuroscience