Author

Thea A. Egelhofer

University of California, Santa Cruz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andreas RechtsteineriD· 2 shared Susan StromeiD· 2 shared Alexander Maxwell BurroughsiD· 1 shared Andrew Kekūpaʻa KnutsoniD· 1 shared Jacob M. GarriguesiD· 1 shared Joshua A. ArribereiD· 1 shared Lakshminarayanan AravindiD· 1 shared Lisa N. PetrellaiD· 1 shared

Activity by Year

2017-2020 · peak 1/yr

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10 top collaborators · 18 mutual co-author links

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2 shared papersGenetics

Andreas RechtsteinerORCID

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3 papers

Recent·Most cited

NONU-1 encodes a conserved endonuclease required for mRNA translation surveillance

Marissa L. Glover, Alexander Maxwell Burroughs, Parissa C. Monem, Thea A. Egelhofer, Makena N. Pule, Lakshminarayanan Aravind, Joshua A. Arribere

The paper identifies NONU-1 as an endoribonuclease essential for translation surveillance pathways and shows its conservation across species.

Cell Reports · Mar 1, 2020Peer-reviewedMolecular Biology

LIN-15B promotes enrichment of H3K9me2 on the promoters of a subset of germline genes that are repressed in somatic cells in C. elegans

Andreas Rechtsteiner, Meghan E. Costello, Thea A. Egelhofer, Jacob M. Garrigues, Susan Strome, Lisa N. Petrella

The paper shows LIN-15B promotes H3K9me2 enrichment on germline gene promoters, repressing them in somatic cells, with distinct effects compared to DREAM complex mutants.

bioRxiv · Dec 17, 2018 · PreprintGenetics

Germ granules prevent accumulation of somatic transcripts in the adult C. elegans germline

Andrew Kekūpaʻa Knutson, Thea A. Egelhofer, Andreas Rechtsteiner, Susan Strome

This study shows that P granules in C. elegans prevent the accumulation of somatic transcripts in adult germ cells by down-regulating spermatogenesis RNAs and maintaining germ cell fate.

Genetics · Mar 3, 2017Peer-reviewedDevelopmental Biology