Susan Strome

The paper investigates how maternal H3K36 and H3K27 HMTs protect germline immortality by regulating gene expression, particularly on the X chromosome, through the transcription factor LIN-15B.

This study shows that disrupting LIN-35-MuvB interaction in C. elegans impairs DREAM function but not chromatin localization, with limited target gene upregulation compared to LIN-35 loss.

This paper shows that Drosophila Myb can bind to nematode LIN9 and LIN52 proteins and cause a synthetic multivulval phenotype in C. elegans, despite their distant evolutionary divergence.

This study shows that the absence of SET-2 in C. elegans leads to progressive transcriptomic deregulation across generations, resulting in loss of germline identity and sterility.

The paper shows LIN-15B promotes H3K9me2 enrichment on germline gene promoters, repressing them in somatic cells, with distinct effects compared to DREAM complex mutants.

This study shows that P granules in C. elegans prevent the accumulation of somatic transcripts in adult germ cells by down-regulating spermatogenesis RNAs and maintaining germ cell fate.