Andreas Rechtsteiner

The paper presents T2T reference genomes from a multi-generational pedigree to study genetic and epigenetic inheritance across the complete genome.

This study shows that DREAM and E2F:RB complexes can repress cell-cycle genes without HDAC activity, challenging the canonical role of HDACs in this process.

The paper develops a nanopore sequencing method to measure telomere length and finds chromosome-specific and conserved telomere lengths across individuals.

This paper shows that NHR-23 is essential for C. elegans development and apical extracellular matrix structure by regulating gene expression in seam and hypodermal cells.

The paper identifies distinct gene regulation by NHR-23 and SPE-44 during C. elegans spermatogenesis and shows their combined depletion affects additional genes.

This study shows that the absence of SET-2 in C. elegans leads to progressive transcriptomic deregulation across generations, resulting in loss of germline identity and sterility.

The paper shows LIN-15B promotes H3K9me2 enrichment on germline gene promoters, repressing them in somatic cells, with distinct effects compared to DREAM complex mutants.

This study shows that P granules in C. elegans prevent the accumulation of somatic transcripts in adult germ cells by down-regulating spermatogenesis RNAs and maintaining germ cell fate.