Author

Theodore K. Esantsi

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Jonathan S. WeissmaniD· 3 shared Alina GunaiD· 2 shared R.M. VoorheesiD· 2 shared Akshaye Pal· 1 shared Alison J. InglisiD· 1 shared Andrea ArmaniiD· 1 shared Andrew L. CangelosiiD· 1 shared Ángel Gálvez-MerchániD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

Jonathan S. WeissmanORCID

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3 papers

Recent·Most cited

Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites

Anna M. Puszynska, Thao Phuong Nguyen, Andrew L. Cangelosi, Andrea Armani, Justin M. Roberts, Kristin A. Singh, James C. Cameron, Tenzin Tseyang, Grace Y. Liu, Steven Lai, Hans‐Georg Sprenger, Jason Yang, William N. Colgan, Jibril F. Kedir, Kathrin M Kajderowicz, , Jonathan S. Weissman

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

bioRxiv · Sep 25, 2025 · PreprintCell Biology

A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens

Alina Guna, Katharine R. Page, Joseph M. Replogle, Theodore K. Esantsi, Maxine L. Wang, Jonathan S. Weissman, R.M. Voorhees

The paper introduces a dual sgRNA library design for CRISPRi screens to identify genetic modifiers, showing improved sensitivity and specificity in detecting epistatic relationships.

BMC Genomics · Oct 30, 2023Peer-reviewedGenomics

Coupled protein quality control during nonsense mediated mRNA decay

Alison J. Inglis, Alina Guna, Ángel Gálvez-Merchán, Akshaye Pal, Theodore K. Esantsi, Heather R. Keys, Evgeni M. Frenkel, Robert S. Oania, Jonathan S. Weissman, R.M. Voorhees

The paper identifies a targeted degradation pathway for nascent proteins from PTC-containing mRNAs, showing CNOT4's role in coupling NMD with protein quality control.

Journal of Cell Science · May 15, 2023Peer-reviewedMolecular Biology