Anna M. Puszynska

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

This study shows that the cyanobacterial circadian clock, via RpaA, coordinates metabolic programs to maintain energy status and viability under light/dark cycles.