Author

Thomas M. Green

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Abby V. McGeeiD· 1 shared Amy B. GoodaleiD· 1 shared Audrey L GriffithiD· 1 shared Aviad TsherniakiD· 1 shared Berta Escude Velasco· 1 shared Bronte Wen· 1 shared Carolyn KrausiD· 1 shared David E. RootiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Abby V. McGeeORCID

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2 papers

Recent·Most cited

Modular vector assembly enables rapid assessment of emerging CRISPR technologies

Abby V. McGee, Yanjing V. Liu, Audrey L Griffith, Zsofia M Szegletes, Bronte Wen, Carolyn Kraus, Nathan W. Miller, Ryan J. Steger, Berta Escude Velasco, Justin A. Bosch, Jonathan D. Zirin, Raghuvir Viswanatha, Erik J. Sontheimer, Amy B. Goodale, Matthew A. Greene, , John G. Doench

The paper introduces a modular CRISPR vector assembly system called Fragmid, enabling rapid creation and testing of CRISPR technologies through combinatorial design and pooled screening.

Cell Genomics · Mar 1, 2024Peer-reviewedGenomics

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

James M. McFarland, Zandra V. Ho, Guillaume Kugener, Joshua M. Dempster, Philip G. Montgomery, Jordan Bryan, John Michael Krill-Burger, Thomas M. Green, Francisca Vázquez, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Aviad Tsherniak

The paper improves gene dependency estimation from RNAi screens by using model-based normalization and data integration, enhancing accuracy and enabling cross-dataset analysis.

Nature Communications · Oct 29, 2018Peer-reviewedGenomics