Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease
Océane Guillemaud, Kelly Ceyzériat, Thomas Saint-Georges, Karine Cambon, Fanny Petit, Lucile Ben Haim, María-Angeles Carrillo-de Sauvage, Martine Guillermier, Suéva Bernier, Anne‐Sophie Hérard, Charlène Joséphine, Alexis‐Pierre Bemelmans, Emmanuel Brouillet, Philippe Hantraye, Gilles Bonvento, Carole Escartin
This study investigates the role of reactive astrocytes in Alzheimer's disease by modulating the JAK2-STAT3 pathway in 3xTg-AD mice, finding no effect on Tau or amyloid pathology but behavioral changes.
bioRxiv · Oct 8, 2019Neuroscience