Philippe Hantraye

This study evaluates AAV9-miR-ATXN3 in a non-human primate model of SCA3, showing reduced neuropathology through allele-specific silencing of mutant ATXN3.

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.

The paper evaluates an optogenetic construct for vision restoration in non-human primates, demonstrating high temporal resolution and visual acuity above legal blindness.

This study investigates the role of reactive astrocytes in Alzheimer's disease by modulating the JAK2-STAT3 pathway in 3xTg-AD mice, finding no effect on Tau or amyloid pathology but behavioral changes.

This study uses diffusion-weighted magnetic resonance spectroscopy to detect astrocyte reactivity in mice by analyzing changes in myo-inositol diffusion linked to morphological alterations.